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Published on: November 10, 2021
Kidney biomarkers in tropical infections: an update
Daniella Bezerra Duarte1,2,3,4, Maria Carolina Santa Rita Lacerda4, Yara Janaína Porto Ribeiro4
1Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará , Fortaleza, Brazil.
Abstract:
Neglected tropical diseases affect over 1 billion people, and cause 170,000 deaths each year. They result in disability, stigma and disfigurement, and also push families into poverty. Tropical infections can involve the kidney, presenting as a wide variety of ways, varying from transient urinary abnormalities to severe acute kidney injury (AKI). It is important to assess renal function in patients with tropical infections for earlier detection of AKI, appropriate treatment and prevention of Chronic Kidney Disease (CKD) outcome in some of them. There was an exponential increase in research on new kidney biomarkers that were earlier and specific for renal damage but few in the scope of tropical infections. In this review, we focus on kidney biomarkers that are being studied in some of the most prevalent tropical infections such as visceral leishmaniasis, leptospirosis, malaria, schistosomiasis and leprosy. Further studies are needed to evaluate the usefulness of renal biomarkers in the early diagnosis of renal diseases associated with tropical infections.
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