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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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A New "TYK" Tok Era for the Study of Long Noncoding RNAs in Pulmonary Hypertension

Neha Hafeez1, Stephen Y Chan2,3

  • 1Pittsburgh Heart, Lung, Blood Vascular Medicine Institute University of Pittsburgh School of Medicine and UPMC Pittsburgh, Pennsylvania.

American Journal of Respiratory and Critical Care Medicine
|July 30, 2020
PubMed
Abstract

No abstract available in PubMed .

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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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