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SARS-CoV-2: characteristics and current advances in research
Yicheng Yang1,2, Zhiqiang Xiao3, Kaiyan Ye4
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Virology Journal
|July 31, 2020
Summary
This review surveys severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19. It details its origin, evolution, pathogenesis, and treatment, comparing it with SARS-CoV.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health emergency.
- SARS-CoV-2 and SARS-CoV are related but distinct SARS-like coronaviruses with differing characteristics.
Purpose of the Study:
- To provide a comprehensive review of SARS-CoV-2, the virus responsible for COVID-19.
- To investigate the origin and evolution of SARS-CoV-2 in comparison to SARS-CoV.
- To summarize the pathogenesis, clinical manifestations, and treatment of COVID-19.
Main Methods:
- Literature review of recent studies on SARS-CoV-2 and SARS-CoV.
- Comparative analysis of viral structure, epidemiology, and pathology.
- Synthesis of information on COVID-19 pathogenesis, cardiovascular effects, and treatment strategies.
Main Results:
- SARS-CoV-2 and SARS-CoV, while related, exhibit significant differences in viral, epidemiological, and pathological characteristics.
- COVID-19 is associated with significant cardiovascular complications, including myocardial injury and venous thromboembolism.
- Various treatment methods for COVID-19 are being investigated and applied.
Conclusions:
- Understanding the origin, evolution, and distinct features of SARS-CoV-2 is crucial for managing the COVID-19 pandemic.
- Cardiovascular complications are a major concern in COVID-19 patients, necessitating focused research and clinical attention.
- Ongoing research into pathogenesis and treatment is vital for improving patient outcomes.
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