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Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis
Supratim Mahapatra1, Pranjal Chandra1
1Laboratory of Bio-Physio Sensors and Nanobioengineering, School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh 221005, India.
Biosensors & Bioelectronics
|July 31, 2020
Summary
This review details diagnostic strategies for COVID-19, including molecular, immunodiagnostic, and biosensing methods. Early detection of SARS-CoV-2 is crucial for effective pandemic control and treatment.
Area of Science:
- Virology
- Infectious Diseases
- Biotechnology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has caused global disruption.
- Understanding viral dynamics and host-pathogen interactions is critical for control.
- Early and accurate diagnosis is essential for managing the pandemic and informing treatment strategies.
Purpose of the Study:
- To provide a comprehensive review of current and emerging COVID-19 diagnostic strategies.
- To systematically present clinical, genetic, and proteomic biomarkers for COVID-19 detection.
- To offer valuable information for scientists, clinicians, and manufacturers on diagnostic approaches.
Main Methods:
- Review of clinically adopted techniques for COVID-19 detection.
- Inclusion of oligonucleotide-based molecular detection methods.
- Analysis of Point-of-Care immunodiagnostics, radiographical analysis, and biosensing prototypes.
- Tabulation of commercial kits and analytical methods with key operational details.
Main Results:
- Overview of various diagnostic techniques including molecular, immunodiagnostic, and biosensing approaches.
- Detailed insights into commercial diagnostic kits, including developer, brand, detection method, and performance metrics.
- Categorization of analytical methods based on sensing strategies for COVID-19 detection.
Conclusions:
- A comprehensive understanding of diagnostic strategies is vital for combating the COVID-19 pandemic.
- The review highlights the importance of early detection through various advanced diagnostic tools.
- Information presented aims to aid in the development and implementation of effective COVID-19 diagnostic solutions.
