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Related Experiment Video

Updated: Dec 13, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Peripapillary capillary density in acute angle closure crisis and angle closure suspect: A structure, flow and

Riham Shm Allam1, Rasha Mounir Eltanamly1, Karim Adly Raafat1

  • 1Department of Ophthalmology, Faculty of Medicine, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.

European Journal of Ophthalmology
|July 31, 2020
PubMed
Summary

Peripapillary vessel density is reduced in acute angle closure crisis (AACC) eyes compared to suspects and controls. Optical Coherence Tomography Angiography (OCT-A) may offer a more sensitive marker post-AACC than OCT alone.

Keywords:
RPC%acute angle closure crisisprimary angle closure suspectstructure/function/flow correlation

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Area of Science:

  • Ophthalmology
  • Vascular Imaging
  • Glaucoma Research

Background:

  • Acute angle closure crisis (AACC) and primary-angle closure-suspects (PACS) represent significant ocular conditions.
  • Understanding peripapillary vascular changes is crucial for diagnosing and managing these conditions.
  • Optical Coherence Tomography Angiography (OCT-A) offers advanced imaging capabilities for microvascular assessment.

Purpose of the Study:

  • To investigate peripapillary vascular changes using OCT-A in patients with AACC and PACS.
  • To compare these vascular changes with those in normal healthy controls.
  • To evaluate OCT-A as a potential diagnostic marker in AACC and PACS.

Main Methods:

  • A cross-sectional study involving 21 eyes with AACC, 21 eyes with PACS, and 32 age-matched controls.
  • Participants underwent visual field (VF) testing, spectral-domain OCT (SD-OCT) for retinal nerve fiber layer (RNFL) assessment, and OCT-A for radial peripapillary capillary density (RPC%) measurement.
  • Correlations between structure (RNFL), function (MD, PSD), and flow (RPC%) were analyzed.

Main Results:

  • Significant differences in mean deviation (MD), pattern standard deviation (PSD), and RNFL thickness were observed across the three groups (p ≤ 0.001).
  • Peripapillary RPC% was significantly decreased in all groups (p ≤ 0.001), with lower density in AACC eyes compared to controls (p = 0.032).
  • Peripapillary RPC% correlated positively with MD and RNFL in AACC eyes, and with RNFL in PACS and control eyes.

Conclusions:

  • Peripapillary vessel density is diminished in AACC eyes compared to PACS and control eyes.
  • OCT-A parameters may serve as more sensitive indicators than OCT parameters following AACC, as suggested by ROC analysis.
  • No significant differences in OCT or OCT-A parameters were found between PACS and normal controls, supporting clinical diagnosis for PACS.