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Updated: Dec 13, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

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[Pediatric acute liver failure]

Angie Milena Cárdenas1, Claudia Jimena Ortiz Rivera2, Roberto Andrés Correa3

  • 1Universidad Libre Cali, Colombia.

Revista Chilena De Pediatria
|July 31, 2020
PubMed

Insights

Acute liver failure (ALF) in children is a serious condition needing prompt care. Early diagnosis and age-specific tests are crucial for effective treatment, though liver transplant consensus is lacking.

Area of Science:

  • Pediatric Hepatology
  • Critical Care Medicine

Background:

  • Acute liver failure (ALF) is a rare but critical pediatric condition.
  • Requires a multidisciplinary approach for timely diagnosis and management.

Purpose of the Study:

  • To provide an updated review of definitions, management strategies, and treatments for pediatric ALF.
  • To synthesize current knowledge on pediatric acute liver failure.

Main Methods:

  • Comprehensive literature review from 2000-2020 across multiple databases (PubMed, LILACS, BIREME, Google Scholar, UpToDate).
  • Utilized specific search terms and filters for age, publication date, and study types (clinical trials, reviews, systematic reviews, case-control).
  • Prioritized highly cited and recent publications.

Main Results:

  • Pediatric ALF necessitates pediatric intensive care unit support.
  • Early diagnosis is key to initiating appropriate treatment.
  • Age-specific diagnostic testing is recommended for pediatric ALF patients.

Conclusions:

  • There is no established consensus on liver transplantation for pediatric ALF cases.
  • Continued research and collaboration are vital for improving outcomes in pediatric ALF.

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