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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity

Thao N D Pham1,2, Christina Spaulding1,2, Hidayatullah G Munshi1,2,3

  • 1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Cancers
|August 1, 2020
PubMed

Insights

MAPK-interacting protein kinases (MNK) drive cancer, and inhibitors are in development. This review explores MNK

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • MAPK-interacting protein kinases (MNK) are implicated in human cancers.
  • MNK activity influences mRNA translation, impacting cancer development and therapy resistance.
  • MNK signaling also regulates innate and adaptive immunity.

Purpose of the Study:

  • To systematically review the function of MNK kinases in immune cells.
  • To elucidate the role of MNK-mediated signals in immune regulation.
  • To inform the development of MNK inhibitors with improved therapeutic efficacy and reduced side effects.

Main Methods:

  • Systematic literature review.
  • Analysis of MNK kinase function and substrates in immune cells.
  • Review of MNK signaling pathways relevant to immunity.

Main Results:

  • MNK kinases play a significant role in modulating immune cell function.
  • MNK-mediated signals impact both innate and adaptive immune responses.
  • Understanding these roles is crucial for optimizing MNK inhibitor therapies.

Conclusions:

  • MNK kinases are critical regulators of the immune system.
  • Targeting MNK in cancer therapy requires careful consideration of immune effects.
  • Further research into MNK-immune interactions can guide safer and more effective cancer treatments.
Keywords:
MNK kinasesSproutyeIF4EhnRNP A1immune responseslymphocytesmacrophagesneutrophilstumor immune microenvironment (TIME)

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