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Related Concept Videos

Cells of the Innate Immune Response01:28

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: Dec 13, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity.

Thao N D Pham1,2, Christina Spaulding1,2, Hidayatullah G Munshi1,2,3

  • 1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Cancers
|August 1, 2020
PubMed
Summary
This summary is machine-generated.

MAPK-interacting protein kinases (MNK) drive cancer, and inhibitors are in development. This review explores MNK

Keywords:
MNK kinasesSproutyeIF4EhnRNP A1immune responseslymphocytesmacrophagesneutrophilstumor immune microenvironment (TIME)

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Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • MAPK-interacting protein kinases (MNK) are implicated in human cancers.
  • MNK activity influences mRNA translation, impacting cancer development and therapy resistance.
  • MNK signaling also regulates innate and adaptive immunity.

Purpose of the Study:

  • To systematically review the function of MNK kinases in immune cells.
  • To elucidate the role of MNK-mediated signals in immune regulation.
  • To inform the development of MNK inhibitors with improved therapeutic efficacy and reduced side effects.

Main Methods:

  • Systematic literature review.
  • Analysis of MNK kinase function and substrates in immune cells.
  • Review of MNK signaling pathways relevant to immunity.

Main Results:

  • MNK kinases play a significant role in modulating immune cell function.
  • MNK-mediated signals impact both innate and adaptive immune responses.
  • Understanding these roles is crucial for optimizing MNK inhibitor therapies.

Conclusions:

  • MNK kinases are critical regulators of the immune system.
  • Targeting MNK in cancer therapy requires careful consideration of immune effects.
  • Further research into MNK-immune interactions can guide safer and more effective cancer treatments.