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Related Concept Videos

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The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
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Related Experiment Video

Updated: Dec 13, 2025

Creation of Abdominal Adhesions in Mice
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Does Human Amnion Membrane Prevent Postoperative Abdominal Adhesions?

Hannah M Nemec1, Hany Atalah1, Melissa Kling1

  • 1The Medical Center, Navicent Health/Mercer University School of Medicine, Macon, GA, USA.

The American Surgeon
|August 1, 2020
PubMed
Summary

Aerosolized human amnion-derived matrix particulate solution (HAMPS) showed a trend toward reducing post-surgical adhesions in rats. Further studies are needed to confirm the efficacy of HAMPS in preventing intra-abdominal adhesions.

Keywords:
adhesionhuman amnion membraneprevention

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Area of Science:

  • Surgical innovation
  • Biomaterials science
  • Regenerative medicine

Background:

  • Postoperative adhesions are a common complication of intra-abdominal surgery, causing significant morbidity.
  • Current methods to prevent adhesions are insufficient.
  • Human amnion-derived matrix shows promise in promoting healing and reducing scar tissue.

Purpose of the Study:

  • To investigate the efficacy of aerosolized human amnion-derived matrix particulate solution (HAMPS) in preventing intra-abdominal adhesions in a rat model.
  • To evaluate the dose-dependent effect of HAMPS on adhesion formation.

Main Methods:

  • A rat model of cecal abrasion was used to induce adhesions.
  • Rats were divided into a control group and three treatment groups receiving different concentrations of HAMPS (6.25, 12.5, and 25 mg/cc).
  • Adhesion assessment was performed 30 days post-surgery.

Main Results:

  • All groups exhibited minimal adhesions, with a trend towards lower average adhesion scores in the HAMPS treatment groups compared to the control.
  • Moderate inflammation was reduced in the treatment groups (11%) versus the control group (33%).
  • A trend toward statistical significance (P = .054) was observed in the 12.5 mg/cc HAMPS group.

Conclusions:

  • HAMPS demonstrated an observational decrease in adhesions and inflammation post-abdominal surgery in rats.
  • A trend toward significance was noted with the 12.5 mg/cc concentration, suggesting potential efficacy.
  • Further research is warranted to validate these findings and explore optimal concentrations for adhesion prevention.