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The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children

Yuanyuan Li1,2, Ziyao Guo1,2, Guangli Zhang3

  • 1Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, 400014, China.

BMC Pediatrics
|August 1, 2020
PubMed
Abstract

Insights

Lower vitamin A levels are linked to refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Maintaining adequate vitamin A status may help reduce RMPP incidence and severity.

Area of Science:

  • Pediatric Infectious Diseases
  • Nutritional Immunology
  • Respiratory Medicine

Background:

  • Vitamin A is crucial for immune function and respiratory health.
  • Infections can alter vitamin A status, necessitating adjustments for acute phase proteins.
  • The relationship between vitamin A levels and refractory Mycoplasma pneumoniae pneumonia (RMPP) in children is not well understood.

Purpose of the Study:

  • To investigate the association between adjusted vitamin A concentrations and the incidence of RMPP.
  • To explore the correlation between vitamin A levels and clinical outcomes in children with Mycoplasma pneumoniae pneumonia (MPP).

Main Methods:

  • A retrospective study of 181 MPP patients, comparing RMPP and general MPP (GMPP) groups.
  • Analysis of adjusted vitamin A concentrations and other clinical parameters.
  • Multivariate logistic regression and linear correlation tests were used to assess associations.

Main Results:

  • Vitamin A concentrations were significantly lower in the RMPP group compared to the GMPP group.
  • Lower vitamin A levels were independently associated with a higher incidence of RMPP.
  • Vitamin A concentrations showed a negative correlation with fever duration and length of stay.

Conclusions:

  • Adjusted serum vitamin A concentrations are independently associated with RMPP incidence in children.
  • Maintaining adequate vitamin A status may play a role in reducing the occurrence and severity of RMPP.
Keywords:
Mycoplasma Pneumoniae pneumonia (MPP)Retinol-binding protein (RBP)Vitamin a

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