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Updated: Dec 13, 2025

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

Brain death evaluation during the pandemic.

Ibrahim Migdady¹, Alexander Rae-Grant¹, David M Greer²

¹From the Division of Neurocritical Care (I.M.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Neurology (A.R.-G.), Cleveland Clinic Foundation, Cleveland, OH; and Department of Neurology (D.M.G.), Boston University Medical Center, Boston, MA.

|August 1, 2020

Summary

This summary is machine-generated.

Diagnosing brain death in COVID-19 patients presents unique challenges. This article offers guidance to safely perform apnea testing and maintain brain death determination standards during the SARS-CoV-2 pandemic.

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Last Updated: Dec 13, 2025

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Published on: June 3, 2020

Area of Science:

Neurology
Infectious Diseases
Critical Care Medicine

Background:

Coronavirus disease 2019 (COVID-19) presents diagnostic challenges in neurological assessments.
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can complicate patient management.
Traditional apnea testing carries risks of aerosol generation and complications in SARS-CoV-2 patients.

Purpose of the Study:

To identify and address the unique challenges in diagnosing brain death in COVID-19 patients.
To provide guidance on safely conducting apnea testing during the SARS-CoV-2 pandemic.
To emphasize the critical importance of adhering to brain death determination standards.

Main Methods:

Discussion of challenges associated with apnea testing in SARS-CoV-2 infected patients.
Review of potential complications related to SARS-CoV-2 lung disease during neurological examination.
Development of strategies to minimize risks for healthcare professionals and other patients.

Main Results:

Apnea testing poses aerosol generation risks.
SARS-CoV-2 related lung disease can complicate the procedure.
Modified approaches are necessary to ensure safety.

Conclusions:

Modified apnea testing protocols are essential for COVID-19 patients.
Maintaining rigorous standards for brain death determination is crucial.
Protecting healthcare workers and other patients is paramount.