Related Experiment Video

Updated: Dec 13, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

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Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases

Manman Dou1, Ying Chen1, Jian Hu1

  • 1Department of Neurology, The First Hospital of Jilin University, Changchun 130021, China.

Biomed Research International
|August 1, 2020
PubMed

Insights

Atherosclerosis underlies cardiovascular and cerebrovascular diseases. This review explores the TSP-1/CD47/VEGF/VEGFR2 pathway and inflammatory factors like IL-1 and NLRP3 as key players in atherosclerosis pathogenesis.

Area of Science:

  • Cardiovascular biology
  • Molecular mechanisms of disease
  • Inflammation research

Background:

  • Atherosclerosis leads to debilitating cardiovascular and cerebrovascular diseases.
  • Understanding atherosclerosis mechanisms is crucial for disease control and prevention.
  • Thrombospondin-1 (TSP-1) exhibits antiangiogenic properties, interacting with its receptor CD47.

Purpose of the Study:

  • To review the pathogenesis of atherosclerosis.
  • To elucidate the role of the TSP-1/CD47/VEGF/VEGFR2 signaling pathway in atherosclerosis.
  • To examine the influence of inflammatory factors on atherosclerosis progression.

Main Methods:

  • Literature review focusing on molecular and cellular mechanisms.
  • Analysis of signaling pathways involved in angiogenesis and inflammation.
  • Synthesis of current research on atherosclerosis pathogenesis.

Main Results:

  • TSP-1/CD47 signaling negatively regulates angiogenesis by affecting VEGF and its downstream targets.
  • The TSP-1/CD47/VEGF/VEGFR2 axis is implicated in the development and progression of atherosclerosis.
  • Inflammatory factors, including IL-1 and NLRP3, significantly impact atherosclerotic processes.

Conclusions:

  • The TSP-1/CD47/VEGF/VEGFR2 pathway represents a critical target for modulating atherosclerosis.
  • Inflammation plays a pivotal role in atherosclerosis pathogenesis.
  • Further research into these pathways may reveal novel therapeutic strategies for cardiovascular and cerebrovascular diseases.

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