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Recent progress on the Chinese space programme and radiation research.

G Zhou1,2, W Hu1,2, H Pei1,2

  • 1State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Institute of Life Sciences in Space, Medical College of Soochow University, Suzhou 215123, China;

Annals of the ICRP
|August 1, 2020
PubMed
Summary
This summary is machine-generated.

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Chinese space radiobiologists are researching space radiation risks for astronauts. Studies explore cancer models, microRNA networks, and cell radioresistance to develop countermeasures for the Chinese Space Station.

Area of Science:

  • Space Biology and Radiobiology
  • Astrobiology and Space Medicine

Background:

  • China's manned space program, initiated in 1992, is advancing towards establishing the Chinese Space Station (CSS) for on-orbit research.
  • Space radiation poses significant health risks, particularly carcinogenesis, for astronauts undertaking long-duration missions.
  • Developing robust risk assessment systems and effective countermeasures is crucial for astronaut safety.

Purpose of the Study:

  • To investigate the biological effects of space radiation relevant to astronaut health.
  • To elucidate molecular mechanisms underlying radiation-induced cellular damage and radioresistance.
  • To inform the development of protective strategies against space radiation for future space exploration.

Main Methods:

  • Established cancer models using low-dose-rate alpha particle exposure.
Keywords:
Bystander effectChinese Space StationLncRNARAC2Space radiation

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  • Investigated molecular networks, including microRNA-TGFβ and lncRNA-cytoskeleton interactions.
  • Assessed the radioresistance of quiescent cells.

    • Main Results:

    • Identified a microRNA-TGFβ network regulating bystander effects.
    • Elucidated a lncRNA-cytoskeleton network involved in genomic instability.
    • Confirmed radioresistance in quiescent cells, suggesting a potential protective strategy.

    Conclusions:

    • Understanding space radiation's impact on biological systems is vital for long-term manned missions.
    • Molecular insights into radiation effects and cellular responses can guide the development of countermeasures.
    • A multidisciplinary approach is essential for mitigating the risks of highly energized space radiation.