Related Experiment Video
Updated: Dec 13, 2025

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
[Calcium scoring and cardiovascular risk assessment in patients with schizophrenia]
Trine Trab, René Ernst Nielsen, Jens Brøndum Frøkjær
1svend.eggert.jensen@rn.dk.
Insights
Patients with schizophrenia have higher mortality from coronary artery disease due to undertreated cardiovascular risk factors. Current risk models are insufficient; coronary artery calcium scoring (CACS) may improve cardiovascular risk assessment in this population.
Area of Science:
- Cardiology
- Psychiatry
- Radiology
Background:
- Coronary artery disease (CAD) significantly increases mortality in schizophrenia patients.
- Cardiovascular (CV) risk factors are often undertreated in this population.
- General population CV risk models inadequately predict mortality in schizophrenia.
Purpose of the Study:
- To evaluate the potential utility of coronary artery calcium scoring (CACS) for improving CV risk prediction in schizophrenia patients.
- To highlight the need for better CV risk assessment tools in individuals with schizophrenia.
Main Methods:
- Review of existing literature on CAD, schizophrenia, and CV risk prediction.
- Discussion of the role of cardiac CT-scan in measuring CACS.
- Analysis of the limitations of current risk prediction models for schizophrenia.
Main Results:
- Standard CV risk prediction models are insufficient for schizophrenia patients.
- Coronary artery calcium scoring (CACS) is a validated tool for CV risk prediction in the general population.
- CACS has not been previously investigated in the schizophrenia population.
Conclusions:
- CACS may offer improved cardiovascular risk assessment and guide treatment in patients with schizophrenia.
- Further research is warranted to investigate the efficacy of CACS in this specific patient group.
- Addressing undertreated CV risk factors is crucial for reducing mortality in schizophrenia.
Abstract:
Coronary artery disease is a major contributor to increased mortality rates in patients with schizophrenia in whom less treatment of cardiovascular (CV) risk factors is seen. Risk prediction models used in the general population are not sufficient to predict CV mortality in patients with schizophrenia. Measurement of calcium score (CACS) by cardiac CT-scan improves risk prediction in the general population, but has not been investigated in patients with schizophrenia. CACS might contribute to improved CV risk assessment and treatment in these patients and further studies should address this.
Related Concept Videos
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Imaging Studies for Cardiovascular System V: CT
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Imaging Studies for Cardiovascular System IV: CMRI
Dysrhythmias V: Evaluating Dysrhythmias

