Carbon nanostructures: The drug and the delivery system for brain disorders

Neurodegenerative disorders and brain tumors are major pathological conditions affecting the brain. The delivery of therapeutic agents into the brain is not as easy as to other organs or systems. The presence of the blood-brain barrier (BBB) makes the drug delivery into the brain more complicated and challenging. Many techniques have been developed to overcome the difficulties with BBB and to achieve brain-targeted drug delivery. Incorporation of the drugs into nanocarriers capable to penetrate BBB is a simple technique. Different nanocarriers have been developed including polymeric nanoparticles, carbon nanoparticles, lipid-based nanoparticles, etc. Carbon nanostructures could make a superior position among them, because of their good biocompatibility and easy penetration of BBB. Carbon-family nanomaterials consist of different carbon-based structures including zero-dimensional fullerene, one-dimensional carbon nanotube, two-dimensional graphene, and some other related structures like carbon dots and nanodiamonds. They can be used as efficient carriers for drug delivery into the brain. Apart from the drug delivery applications, they can also be used as a central nervous system (CNS) therapeutic agent; some of the carbon nanostructures have neuroregenerative activity. Their influence on neuronal growth and anti-amyloid action is also interesting. This review focuses on different carbon nanostructures for brain-targeted drug delivery and their CNS activities. As a carrier and CNS therapeutic agent, carbon nanostructures can revolutionize the treatment of brain disorders.