[Theoretical discussion on stress and its projection to pathology]

The stress is presented in the perspective of an automatic response related to hereditary behavior, where the threat played the role of a a basic stressor. Thus only offensive or disagreeable agents are accepted as stressors, a point of theoretical important implications. The demonstration that only the inescapable chronic stressor produces immunodepression enriched the transformation of a pathogenic factor into a pathological event by means of the repeated stress reaction.