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Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review.

Ana Luiza Cabrera Martimbianco1, Rafael Leite Pacheco1, Fábia Lima Vilarino1

  • 1Department of Medicine, Centro Universitário São Camilo, São Camilo, SP, Brazil.

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Tribulus terrestris may improve sexual function in women, but evidence is limited. More research is needed to confirm the effectiveness and safety of this herbal supplement for female sexual dysfunction (FSD).

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Area of Science:

  • Integrative Medicine and Women's Health
  • Pharmacology and Herbal Medicine Research

Background:

  • Female sexual dysfunction (FSD) is a prevalent concern affecting women's quality of life.
  • Herbal remedies, including Tribulus terrestris, are explored as potential treatments for FSD.

Purpose of the Study:

  • To systematically review and assess the effectiveness and safety of Tribulus terrestris for treating female sexual dysfunction (FSD).
  • To evaluate the quality of evidence from randomized controlled trials (RCTs) investigating Tribulus terrestris for FSD.

Main Methods:

  • Conducted comprehensive electronic searches across multiple databases (MEDLINE, CENTRAL, EMBASE, etc.).
  • Included 5 randomized controlled trials (RCTs) involving 279 participants comparing Tribulus terrestris with placebo or active interventions.
  • Assessed risk of bias using the Cochrane Risk of Bias tool and certainty of evidence with GRADE.

Main Results:

  • Tribulus terrestris treatment led to significant improvements in sexual function scores for premenopausal and postmenopausal women after 1-3 months.
  • A significant increase in serum testosterone levels was observed in premenopausal women after three months of treatment.
  • No serious adverse events were reported; however, the certainty of the evidence was rated as very low.

Conclusions:

  • Current evidence suggests a potential benefit of Tribulus terrestris for FSD, but the low certainty of evidence necessitates caution.
  • Further high-quality randomized controlled trials (RCTs) are required to confirm these findings and establish efficacy and safety.
  • Shared decision-making between patients and clinicians is crucial, considering the uncertainties surrounding Tribulus terrestris' effects.