Related Experiment Video
Updated: Dec 13, 2025

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
Published on: August 5, 2020
Defining Death: Lessons From the Case of Jahi McMath
1Division of Critical Care Medicine, Department of Anesthesia, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts robert_truog@hms.harvard.edu.
Brain death is not biological death, as some patients diagnosed with brain death survive for years. Reframing brain death as a social construct may align legal and ethical practices with medical realities.
Area of Science:
- Neurology
- Bioethics
- Forensic Medicine
Background:
- Biological death is defined as irreversible loss of organism function, typically post-cardiorespiratory arrest.
- Neurological death (brain death) was proposed in 1968 as irreversible loss of brain function, presumed equivalent to biological death.
- The presumed equivalence of brain death and biological death is challenged by cases of prolonged survival after brain death diagnosis.
Discussion:
- Numerous cases demonstrate patients diagnosed as brain-dead surviving for extended periods, contradicting the certainty of rapid cardiorespiratory arrest.
- The Jahi McMath case highlights the prolonged survival of a brain-dead individual, supported by medical interventions.
- This discrepancy raises ethical concerns regarding the dead donor rule for organ procurement from brain-dead individuals.
Key Insights:
- Brain death is not synonymous with biological death; patients can survive for years after neurological criteria for death are met.
- The traditional understanding of brain death equivalence to biological death is scientifically inaccurate.
- The ethical and legal frameworks surrounding organ donation require re-evaluation in light of prolonged survival post-brain death.
Outlook:
- Advocating for reframing brain death as a "social construct" to reconcile medical findings with societal acceptance.
- Proposing that patients diagnosed as brain-dead be legally and ethically treated as biologically dead.
- This reframing aims to ensure consistent ethical and legal practices in end-of-life care and organ donation.
Related Concept Videos
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Ethical Dilemmas II
Kubler Ross's Stages of Dying
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Free-falling Bodies: Example
The...
Free-falling Bodies: Introduction

