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Association between periodontitis and vascular endothelial function using noninvasive medical device-A pilot study
Takahito Fujitani1, Norio Aoyama1, Fumihiko Hirata2
1Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, Yokosuka, Japan.
Clinical and Experimental Dental Research
|August 2, 2020
Summary
Periodontal disease, particularly tooth mobility, is linked to endothelial dysfunction, an early sign of cardiovascular disease. This study highlights the connection between oral health and vascular health.
Area of Science:
- Cardiovascular Health
- Periodontology
- Vascular Biology
Background:
- Periodontitis is increasingly associated with cardiovascular diseases.
- Endothelial dysfunction is a critical early step in atherosclerosis.
- Limited research exists on the direct link between periodontal disease and endothelial dysfunction.
Purpose of the Study:
- To investigate the relationship between periodontal status and endothelial function.
- To assess endothelial function using a noninvasive device.
- To identify specific periodontal parameters associated with endothelial dysfunction.
Main Methods:
- Recruited 33 subjects from a private medical clinic.
- Measured vascular endothelial function noninvasively.
- Assessed periodontal parameters: probing pocket depth, attachment level, tooth mobility, and oral hygiene.
- Categorized subjects into groups based on endothelial function scores.
Main Results:
- Subjects with endothelial dysfunction showed increased tooth mobility and a higher number of lost teeth.
- The endothelial dysfunction group had a higher prevalence of elderly individuals and altered hemoglobin A1c levels.
- Multiple logistic regression identified increased tooth mobility as an independent predictor of endothelial dysfunction.
Conclusions:
- Increased tooth mobility, a key periodontal indicator, is significantly associated with endothelial dysfunction.
- This finding suggests a potential link between poor oral health and early-stage vascular impairment.
- Further research is warranted to explore the mechanisms underlying this association.
