Related Experiment Video
Updated: Jul 10, 2026

Impact of Common Fruit Juices and Toothbrushing on the Discoloration of Primary Teeth
Published on: March 27, 2026
Effectiveness in Remineralizing White Spot Lesions in Primary Teeth With Varnishes: A Systematic Review
Carolina Caleza-Jiménez1, María Biedma-Perea1, David Ribas-Pérez1
1Department of Stomatology, University of Seville, Seville, Spain.
Objectives:
This systematic review aims to assess the effectiveness of varnishes for the remineralization of white spot lesions in primary teeth.
Methods:
A database search was conducted in MEDLINE and the Cochrane Library to screen for articles relevant to the topic of the review. Risks of bias in randomized studies were assessed using the ROB2 tool and GRADE evidence levels.
Results:
Seven studies met all inclusion criteria and were included. Differences in varnish composition and characteristics can affect the anticaries properties. Bioactive additives had a statistically significant reduction in ICDAS scores.
Conclusions:
Intensive application of remineralizing varnishes demonstrated a significant effect on the remineralization and control of carious lesion activity. New-generation fluoride appear to be more effective than conventional sodium fluoride varnishes.
