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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

Michael L van de Weijer1, Logesvaran Krshnan1, Sabrina Liberatori1

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Molecular Cell
|August 2, 2020
PubMed
Summary

Researchers discovered a new pathway for degrading misfolded membrane proteins in the endoplasmic reticulum (ER). This ER-associated degradation (ERAD) branch involves a specific ER membrane complex, offering insights into protein quality control.

Keywords:
ER-associated degradationERADRNF185TEB4/MARCH6TMEM259TMUB1/TMUB2UBE3Cendoplasmic reticulummembralinprotein quality control

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