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Characteristics and Outcomes of Hospitalized Young Adults with Mild Covid -19
Arvind Kumar Sharma1, Asrar Ahmed2, Vaseem Naheed Baig1
1Department of Community Medicine, RUHS College of Medical Sciences, Rajasthan.
Insights
Mild COVID-19 cases in India, particularly younger patients, show excellent recovery. Most patients experienced mild symptoms, with rapid virus clearance and uncomplicated hospital stays, leading to all being discharged alive.
Area of Science:
- Infectious Diseases
- Epidemiology
- Public Health
Background:
- COVID-19 has a severe course in hospitalized adults in high- and middle-income countries.
- Clinical outcomes of mild COVID-19 in Indian hospitalized patients were assessed.
Purpose of the Study:
- To evaluate the clinical outcomes of consecutively hospitalized patients with mild coronavirus disease 2019 (COVID-19) in India.
Main Methods:
- A case registry of 501 patients admitted with suspected COVID-19 was established.
- COVID-19 diagnosis was confirmed via reverse transcriptase polymerase chain reaction (RT-PCR).
- Demographic, clinical, investigation, and outcome data were collected and analyzed using descriptive statistics.
Main Results:
- COVID-19 was diagnosed in 234 patients (46.7%); 49% had a history of BCG vaccination compared to 10% of controls.
- Mildly symptomatic or asymptomatic young patients (<40 years) showed rapid virus clearance (10.2±6.4 days).
- One patient required oxygen support; all others had uncomplicated hospital courses and were discharged alive.
Conclusions:
- Hospitalized, mildly symptomatic or asymptomatic young COVID-19 patients in India demonstrate an excellent prognosis.
- The study highlights the generally favorable outcomes for mild COVID-19 cases in this demographic.
- BCG vaccination history and age influenced virus clearance rates.
Background:
Stormy course has been reported among hospitalized adults with COVID-19 in high- and middle-income countries. To assess clinical outcomes in consecutively hospitalized patients with mild covid-19 in India we performed a study.
Methods:
We developed a case registry of successive patients admitted with suspected covid-19 infection to our hospital (n=501). Covid-19 was diagnosed using reverse transcriptase polymerase chain reaction (RT-PCR). Demographic, clinical, investigations details and outcomes were recorded. Descriptive statistics are presented.
Results:
Covid-19 was diagnosed in 234 (46.7%) and data compared with 267 (53.3%) negative controls. Mean age of covid-19 patients was 35.1±16.6y, 59.4% were <40y and 64% men. Symptoms were in less than 10% and comorbidities were in 4-8%. History of BCG vaccination was in 49% cases vs 10% controls. Cases compared to controls had significantly greater white cell (6.96+1.89 vs 6.12+1.69x109 cells/L) and lower lymphocyte count (1.98+0.79 vs 2.32+0.91x109 cells/L). No radiological and electrocardiographic abnormality was observed. All these were isolated or quarantined in the hospital and observed. Covid-19 patients received hydroxychloroquine and azithromycin according to prevalent guidelines. One patient needed oxygen support while hospital course was uncomplicated in the rest. All were discharged alive. Conversion to virus negative status was in 10.2±6.4 days and was significantly lower in age >40y (9.1±5.2) compared to 40-59y (11.3±6.1) and ≥60y (16.4±13.3) (p=0.001).
Conclusions:
This hospital-based registry shows that mildly symptomatic or asymptomatic young covid-19 patients have excellent prognosis.
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