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Updated: Dec 13, 2025

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Multi-vendor multi-site T_1ρ and T₂ quantification of knee cartilage.

J Kim¹, K Mamoto¹, R Lartey¹

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.

Osteoarthritis and Cartilage

|August 3, 2020

Summary

This study demonstrates reproducible T1ρ and T2 measurements for knee cartilage across multiple MRI vendors and sites. These findings support the use of these quantitative imaging techniques in large-scale clinical trials.

Keywords:

Cartilage imaging Magnetic resonance imaging Repeatability Reproducibility T(1ρ)T(2)

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Last Updated: Dec 13, 2025

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Area of Science:

Biomedical Imaging
Radiology
Quantitative MRI

Background:

Standardizing quantitative MRI techniques like T1ρ and T2 is crucial for multi-center studies.
Variability in MRI systems and protocols can affect the reliability of cartilage measurements.
Developing harmonized imaging sequences is essential for reproducible knee cartilage assessment.

Purpose of the Study:

To develop and validate a 3D T1ρ and T2 imaging sequence applicable across different MRI vendors.
To assess the intra-site repeatability and inter-site, inter-vendor reproducibility of knee cartilage T1ρ and T2 measurements.
To establish the feasibility of using these quantitative MRI measures in multi-site, multi-vendor clinical trials.

Main Methods:

Implemented a 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) sequence.
Collected data using 3T MRI systems from Siemens, GE, and Philips across four sites with harmonized protocols.
Evaluated repeatability and reproducibility using phantom data and volunteer scans, including traveling subject studies.

Main Results:

Achieved low intra-site coefficients of variation (CVs) for T1ρ (1.09-3.93%) and T2 (1.44-4.08%) in both phantoms and volunteers.
Demonstrated acceptable inter-site CVs for T1ρ (5.23-8.14%) and T2 (6.45-10.06%) across different vendors and sites.
Phantom and volunteer data showed consistent results, indicating robust performance of the 3D MAPSS sequence.

Conclusions:

The developed 3D MAPSS sequence shows promising multi-site, multi-vendor reproducibility for T1ρ and T2 knee cartilage measurements.
Harmonized sequence structure and centralized processing enable reliable quantitative MRI in diverse clinical settings.
These quantitative measures are suitable for application in large-scale, multi-center, multi-vendor clinical trials for knee cartilage evaluation.