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Updated: Dec 13, 2025

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
Published on: June 10, 2018
Parallel derivation of X-monosomy induced pluripotent stem cells (iPSCs) with isogenic control iPSCs
Anis Feki1, Frédérique Sloan-Béna2, Youssef Hibaoui1
1Service de gynécologie obstétrique, HFR Fribourg - Hôpital cantonal, Chemin des Pensionnats 2-6, Case postale, 1708 Fribourg, Switzerland; Stem Cell Research Laboratory, Department of Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland.
Abstract:
Turner syndrome, caused by partial or complete loss of one copy of X-chromosome (45,X), is the most common sex chromosome abnormality in women with an incidence of 1 in 2500 female births. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) carrying X-monosomy anomaly, with isogenic control iPSCs. Among the iPSC lines generated from 46XX-fibroblasts, one spontaneously lost a copy of X-chromosome following the reprogramming process, establishing the 45X-iPSC line.
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