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Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat
L Bustos-Fernández1, E González, J A Kofoed
1Instituto de Gastroenterología, Dr. Jorge Pérez Companc, Pontificia Universidad Católica Argentina Santa María de los Buenos Aires.
Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia
|January 1, 1987
Abstract:
Pirenzepine has been widely used for the treatment of gastric and duodenal ulcer. In this work we have proved that this drug could prevent the inflammatory reaction induced in the colon with an intraluminal stimuli as the acetic acid. These data suggest the cholinergic participation in the inflammatory colonic response.