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Methamphetamine and cardiac disease among people with HIV infection

Tcs Martin1, S Gianella1, D Franklin1

  • 1Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA.

HIV Medicine
|August 3, 2020
PubMed

Insights

Methamphetamine use was not linked to heart conditions like myocardial infarction or heart failure in people with HIV. Traditional risk factors and HIV itself were more significant predictors of cardiac disease in this population.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • People living with HIV (PWH) face higher cardiac disease risks.
  • Methamphetamine use is linked to cardiovascular issues but its role in PWH cardiac disease is unexplored.

Purpose of the Study:

  • To investigate the association between methamphetamine use and cardiac disease in people living with HIV.
  • To identify risk factors for myocardial infarction and heart failure in PWH.

Main Methods:

  • A case-control study using data from the HIV Neurobehavioral Research Program.
  • Defined cases as PWH with myocardial infarction or heart failure history.
  • Assessed methamphetamine abuse/dependence and other covariates via logistic regression.

Main Results:

  • Among 3747 PWH, methamphetamine use was not associated with myocardial infarction or heart failure.
  • HIV infection presence and duration were linked to myocardial infarction.
  • Older age, hypertension, and myocardial infarction history were associated with heart failure.

Conclusions:

  • No link found between methamphetamine abuse/dependence and myocardial infarction or heart failure in PWH.
  • Traditional cardiovascular risk factors, HIV presence, and duration are key factors in PWH cardiac disease.
  • Optimal management of traditional cardiovascular risk factors is crucial for PWH.
Abstract

Keywords:
HIVheart failuremethamphetaminesubstance use

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