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C-reactive protein in streptococcal pharyngitis.

E L Kaplan, L W Wannamaker

    Pediatrics
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The C-reactive protein (CRP) test can help distinguish between a true streptococcal infection and a carrier state in children with pharyngitis. A negative CRP result at the initial visit suggests a lower likelihood of infection.

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    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Clinical Chemistry

    Background:

    • Group A streptococcal pharyngitis is a common childhood illness.
    • Differentiating between true infection and asymptomatic carriers can be challenging for clinicians.
    • C-reactive protein (CRP) is an acute-phase reactant often elevated in bacterial infections.

    Purpose of the Study:

    • To evaluate the utility of the C-reactive protein (CRP) test in distinguishing streptococcal pharyngitis from asymptomatic carriage.
    • To assess the correlation between CRP levels and serological markers of streptococcal infection.

    Main Methods:

    • 157 children with symptomatic pharyngitis and positive Group A Streptococcus cultures were enrolled.
    • Serial blood samples were analyzed for C-reactive protein (CRP) presence.

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  • Patients' antibody responses to antistreptolysin O and antistreptococcal deoxyribonuclease B were measured.

    • Main Results:

    • 78% of patients with confirmed streptococcal pharyngitis showed a positive CRP test during the acute visit.
    • A negative CRP test at the initial visit was associated with only a 25% subsequent antibody response.
    • The predictive value of a negative CRP was independent of culture positivity, exudate, adenitis, fever, or coryza.

    Conclusions:

    • The C-reactive protein (CRP) test can be a valuable tool for clinicians in diagnosing streptococcal pharyngitis.
    • A negative CRP result at the time of presentation may indicate a lower probability of true streptococcal infection.
    • Further investigation into CRP's role in acute pharyngitis management is warranted.