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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Dec 13, 2025

Multi-Modal Home Sleep Monitoring in Older Adults
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Sleep and the aging brain. A multifaceted approach.

Angeliki Tsapanou1, Nikolaos Scarmeas1, Yaakov Stern1

  • 1Cognitive Neuroscience Division, Department of Neurology, Columbia University Medical Center - New York - New York.

Sleep Science (Sao Paulo, Brazil)
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Adequate sleep is crucial for maintaining brain health and cognitive function throughout aging. This review explores sleep

Keywords:
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Area of Science:

  • Neuroscience
  • Gerontology
  • Sleep Medicine

Background:

  • Sleep is essential for overall brain health and cognitive function.
  • Age-related cognitive decline and dementia are significant public health concerns.
  • Understanding the sleep-brain relationship is vital for healthy aging.

Purpose of the Study:

  • To review the theoretical background on sleep and brain function.
  • To examine the association between sleep, cognitive performance, and dementia risk.
  • To explore sleep's role in subjective cognitive complaints and brain biomarkers.

Main Methods:

  • Literature review synthesizing existing research.
  • Analysis of studies on sleep and cognitive outcomes.
  • Investigation of sleep's link to subjective complaints and neuroimaging data.

Main Results:

  • Sleep is strongly associated with cognitive performance and changes over time.
  • Sleep disturbances are linked to an increased risk of dementia.
  • Sleep quality correlates with subjective cognitive complaints, even without objective decline.

Conclusions:

  • Sleep plays a vital role in maintaining a healthy aging brain.
  • Specific genes and brain region morphometry are influenced by sleep.
  • A multifactorial approach is necessary to understand the sleep-brain association.