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Updated: Dec 13, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Metallic ureteral stent in restoring kidney function: Nine case reports
Wei Gao1, Tong-Wen Ou2, Xin Cui2
1Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. polarbeargaowei@sina.com.
Background:
Retroperitoneal fibrosis is an exceptionally rare disease characterized by proliferation of fibrous tissue and inflammation in the retroperitoneum. It features many symptoms in the kidneys and in other organs and usually leads to ureteral obstruction.
Case Summary:
Here we present 9 consecutive cases of idiopathic retroperitoneal fibrosis (IRPF) in patients who presented to the Department of Nephrology or Department of Rheumatology, Xuanwu Hospital, Capital Medical University, Beijing, China, between January 2012 and June 2017 with ureteral obstruction due to external compression of the ureter that led to hydronephrosis and kidney dysfunction. Computed tomography imaging was used to identify hydronephrosis and ureteral obstruction and to evaluate kidney function. Each patient was diagnosed with IRPF based on clinical observation and computed tomography examination results. To restore kidney function, a retrograde metallic stent was placed in the ureter under X-ray guidance 2 d after each patient's admission. No perioperative complications occurred in any patient, but postoperative complications occurred in two patients as follows: Patient 2 had stent migration and repeated metallic stent infections that resolved with treatment; and patient 4 had postoperative hematuria because he resumed normal activities too soon after stent placement (contrary to instruction). Placement of the metallic ureteral stents provided relief from ureteral obstruction and restored kidney function in all patients.
Conclusion:
Our 9-case series underscores the utility and efficacy of applying the Resonance® metallic ureteral stent to treat ureteral obstruction in patients with IRPF. For all retroperitoneal fibrosis cases in our series, ureteral stents provided effective relief and were shown to reduce the incidence rate of perioperative and postoperative complications.
Insights
Idiopathic retroperitoneal fibrosis (IRPF) can cause ureteral obstruction. Metallic ureteral stents effectively relieved obstruction and restored kidney function in nine patients, with minimal complications.
Area of Science:
- Nephrology
- Urology
- Radiology
Background:
- Retroperitoneal fibrosis is a rare condition causing fibrous tissue proliferation and inflammation in the retroperitoneum.
- It often affects the kidneys and can lead to ureteral obstruction, hydronephrosis, and kidney dysfunction.
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