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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Related Experiment Video

Updated: Dec 13, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells

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PRMT5 function and targeting in cancer.

Hyungsoo Kim1, Ze'ev A Ronai1

  • 1Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

Cell Stress
|August 4, 2020
PubMed
Summary

Protein arginine methyltransferase 5 (PRMT5) is crucial in cancer development and therapy response. Targeting PRMT5 offers a promising therapeutic strategy for various cancers.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Protein methyl transferases are key regulators in cancer development, progression, and treatment response.
  • PRMT5, a member of the PRMT family, influences oncogenic processes.
  • PRMT5 impacts both tumor-intrinsic and microenvironmental signaling pathways.

Purpose of the Study:

  • To elucidate the multifaceted roles of PRMT5 in cancer.
  • To highlight PRMT5's influence on critical cellular processes relevant to oncogenesis.
  • To establish the therapeutic potential of targeting PRMT5 in cancer treatment.

Main Methods:

  • Review of existing literature on PRMT5 function in cancer.
  • Analysis of PRMT5's impact on histone and protein methylation.
Keywords:
MEP50PRMT1PRMT5histonemethylationmethyltransferasesplicingtranscription

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An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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Related Experiment Videos

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An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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  • Examination of PRMT5's role in RNA splicing, cell cycle, apoptosis, and metabolism.

    • Main Results:

    • PRMT5 regulates key oncogenic processes through epigenetic modifications and protein methylation.
    • PRMT5 affects vital cellular functions including RNA splicing, cell cycle control, cell death, and metabolic signaling.
    • Dysregulation of PRMT5 contributes to cancer development and progression.

    Conclusions:

    • PRMT5 is a critical regulator in cancer, impacting multiple signaling pathways.
    • Understanding PRMT5's function provides a basis for developing targeted cancer therapies.
    • Targeting PRMT5 represents a viable therapeutic strategy for cancer treatment.