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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Aging01:26

Aging

490
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
490
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
116
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

136
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Older Adults' Perspective towards Participation in a Multicomponent Frailty Prevention Program: A Qualitative Study.

R Yu1, M C So, C Tong

  • 1Ruby Yu, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China, Tel: (852) 3943 5142, Fax: (852) 2637 9215,

The Journal of Nutrition, Health & Aging
|August 4, 2020
PubMed
Summary

Older Chinese adults found multi-component frailty prevention programs beneficial for health and social connection. Key motivators for participation included health benefits and peer support, while adherence was linked to social connection and dignity.

Keywords:
Frailtycognitive trainingexercisemulti-component interventionssocial activity

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Area of Science:

  • Gerontology
  • Public Health
  • Community Health

Background:

  • Frailty is a significant concern in aging populations, particularly in older Chinese adults.
  • Community-based interventions are crucial for managing and preventing frailty in older adults.
  • Understanding participant perspectives is vital for designing effective frailty prevention programs.

Purpose of the Study:

  • To explore pre-frail and frail older Chinese individuals' perspectives on a group-based frailty prevention program.
  • To identify factors influencing participation and sustained engagement in such programs.
  • To gather insights for optimizing future frailty intervention designs.

Main Methods:

  • Seven focus groups were conducted with 38 community-dwelling older adults (aged 54-84) screened with pre-frailty or frailty.
  • Participants had completed a 12-week multi-component frailty prevention program (physical, cognitive, social activities).
  • Thematic analysis was employed to analyze qualitative data from the interviews.

Main Results:

  • Perceived health benefits, peer support, and social networking emerged as key motivators for initial program participation.
  • Adherence to the program was motivated by perceived health benefits, socializing, sense of connectedness, expert guidance, and maintaining dignity.
  • Participants reported positive impacts on physical health, psychological well-being, and social life.

Conclusions:

  • Multi-component, group-based frailty prevention programs can positively impact older adults' health and social well-being.
  • Program design should consider factors like health benefits, social connection, expert support, and dignity to enhance participation and adherence.
  • These findings offer valuable insights for developing sustainable community-based frailty interventions for older adults.