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Experience with Real-Time Continuous Glucose Monitoring in Newborns with Congenital Hyperinsulinemic Hypoglycemia

Ayşe Anık1, Münevver Kaynak Türkmen1, Abdullah Barış Akcan1

  • 1Pediatrics, Division of Neonatology, Adnan Menderes University School of Medicine, Aydin, Turkey.

Zeitschrift Fur Geburtshilfe Und Neonatologie
|August 4, 2020
PubMed

Insights

Real-time continuous glucose monitoring (RT-CGMS) accurately assesses glucose levels in newborns with congenital hyperinsulinemic hypoglycemia (CHH) during normal blood sugar. This technology can reduce the need for frequent capillary blood tests in these vulnerable infants.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Medical Devices

Background:

  • Congenital hyperinsulinemic hypoglycemia (CHH) requires vigilant monitoring in children to prevent neurological damage.
  • Current capillary blood glucose monitoring methods are insufficient for detecting all hypoglycemia episodes.

Purpose of the Study:

  • To evaluate the accuracy and effectiveness of a real-time continuous glucose monitoring system (RT-CGMS) in neonates diagnosed with CHH.

Main Methods:

  • RT-CGMS sensors were used in newborn patients for a minimum of 6 days.
  • Bland-Altman analysis was employed to compare RT-CGMS data with capillary blood glucose measurements.

Main Results:

  • A high correlation was observed between RT-CGMS and capillary glucose readings, particularly during normoglycemia.
  • While the false positive rate for hypoglycemia was notable, RT-CGMS demonstrated potential for earlier detection of hypoglycemic events.

Conclusions:

  • RT-CGMS provides accurate glucose monitoring in normoglycemic neonates with CHH.
  • The use of RT-CGMS can significantly decrease the number of required capillary blood samples in pediatric CHH patients.
Abstract

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