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Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility
Wenhao Shen1, Li Xiao2, Yang Li2
1Department of Oncology, Taizhou People's Hospital, Taizhou, 225300, China.
Hereditas
|August 5, 2020
Summary
Single nucleotide polymorphisms (SNPs) in Mannose-binding lectin (MBL2) may influence susceptibility to pulmonary tuberculosis (PTB). A meta-analysis found associations between specific MBL2 SNPs and PTB risk, particularly in Asian populations.
Area of Science:
- Immunogenetics
- Infectious Disease Epidemiology
Background:
- Mannose-binding lectin (MBL2) is crucial for innate immunity against tuberculosis (TB).
- Four common single nucleotide polymorphisms (SNPs) in MBL2 are investigated for their potential link to pulmonary tuberculosis (PTB) risk.
Purpose of the Study:
- To comprehensively analyze the association between MBL2 polymorphisms and PTB risk.
- To evaluate the role of specific MBL2 SNPs in the human immune response to TB.
Main Methods:
- A systematic literature search was conducted across PubMed, Embase, and SinoMed databases up to June 13, 2019.
- Meta-analysis of 37 case-control studies was performed to calculate odds ratios and 95% confidence intervals.
Main Results:
- A positive association was found between the MBL2 rs11003125 polymorphism and PTB risk in hospital-based studies.
- Combined MBL2 polymorphisms showed positive associations with PTB risk in the total population and specifically in individuals of Asian descent.
- No significant associations were identified for MBL2 SNPs rs7096206 and rs7095891.
Conclusions:
- Specific single nucleotide polymorphisms in MBL2 are potentially associated with an increased susceptibility to pulmonary tuberculosis.
- These findings highlight the role of MBL2 genetic variations in the immune response to TB infections.
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