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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 4, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

SECTM1 coordinates immune microenvironments and multi-systemic disease pathophysiology.

Wenqing Yu1, Yusheng Wu1, Mingdong Ding1

  • 1Department of Infectious Diseases, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China.

Frontiers in Immunology
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Secreted and Transmembrane Protein 1 (SECTM1) is a versatile immunomodulator bridging innate and adaptive immunity. This review highlights its expanded roles in diverse diseases and potential for precision immunotherapy.

Keywords:
CD7/GITR axisbiomarkerimmune checkpointinnate-adaptive crosstalksecreted and transmembrane protein 1 (SECTM1)tumor microenvironment

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Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

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Related Experiment Videos

Last Updated: Jun 4, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Secreted and Transmembrane Protein 1 (SECTM1) was initially known as a co-stimulatory molecule interacting with CD7 on T cells.
  • Emerging evidence reveals SECTM1's broader function as a bridge between innate and adaptive immunity.
  • SECTM1 also interacts with receptors like glucocorticoid-induced TNFR-related protein, modulating macrophage and neutrophil activity.

Purpose of the Study:

  • To review the expanded understanding of SECTM1's immunomodulatory functions.
  • To delineate SECTM1's molecular mechanisms in various pathologies.
  • To highlight SECTM1's potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Systematic review of existing literature on SECTM1.
  • Analysis of SECTM1's interactions with immune receptors.
  • Examination of SECTM1's role in diverse disease contexts.

Main Results:

  • SECTM1 acts as a multi-systemic regulator influencing tumor microenvironment, metabolic homeostasis, and tissue regeneration.
  • SECTM1 governs immune cell migration and activation in cancer, cardiovascular, and neurodegenerative diseases.
  • SECTM1 is identified as a marker of "immune-hot" tumors and a potential early diagnostic biomarker.

Conclusions:

  • SECTM1's role extends beyond lymphoid signaling to encompass diverse systemic functions.
  • SECTM1 presents significant clinical potential for precision immunotherapy and regenerative medicine.
  • Further research into SECTM1 mechanisms could unlock novel therapeutic strategies.