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Primary thyroid angiosarcoma in a non-endemic region - a rare case.
Adrian Daniel Tulin1, Adelaida Avino, Laura Răducu
1Department of Plastic and Reconstructive Surgery, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest, Romania; raducu.laura@yahoo.com; Discipline of Internal Medicine I and Nephrology, Department of Medical Semiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Department of Nephrology, Emergency University Hospital, Bucharest, Romania; tanasescu2007@yahoo.com.
Thyroid angiosarcoma (AS), a rare and aggressive vascular tumor, can occur outside endemic regions. This case highlights the importance of considering AS in thyroid nodule differential diagnoses.
Area of Science:
- Oncology
- Pathology
- Vascular Tumors
Background:
- Thyroid angiosarcoma (AS) is an aggressive vascular neoplasm originating from endothelial cells.
- It exhibits characteristic positive staining for endothelial markers, cytokeratins, and epithelial membrane antigen.
- AS is known for high recurrence and metastasis rates.
Observation:
- A 76-year-old patient presented with dyspnea and asthenia.
- Investigations revealed a large right thyroid nodule.
- Immunohistochemical analysis confirmed angiosarcoma.
Findings:
- The thyroid nodule was diagnosed as angiosarcoma based on characteristic pathological markers.
- This diagnosis was made despite the patient not being from a region typically associated with thyroid AS.
- The tumor's aggressive nature was evident from its presentation.
Implications:
- Thyroid angiosarcoma, though rare, should be considered in the differential diagnosis of thyroid nodules, regardless of geographic location.
- Early recognition and diagnosis are crucial for managing this aggressive malignancy.
- Further research may elucidate the broader geographical distribution and risk factors for thyroid AS.
