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DNA Methylation in T-Cell Development and Differentiation

Luis O Correa1, Martha S Jordan2, Shannon A Carty3

  • 1Graduate Program in Immunology, University of Michigan, Ann Arbor, MI.

Critical Reviews in Immunology
|August 5, 2020
PubMed

T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This intricate specification allows for cell-type and context-specific transcriptional programs that regulate immune responses to infection and malignancy. Epigenetic changes, including histone modifications and covalent modification of DNA itself through DNA methylation, are now recognized to play a critical role in these cell-fate decisions. DNA methylation is mediated primarily by the actions of the DNA methyltransferase (DNMT) and ten-eleven-translocation (TET) families of epigenetic enzymes. In this review, we discuss the role of DNA methylation and its enzymatic regulators in directing the development and differentiation of CD4+ and CD8+ T-cells.

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