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Resolution of coronavirus disease 2019 (COVID-19)

Khaled Habas1, Chioma Nganwuchu1, Fanila Shahzad1

  • 1Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.

Expert Review of Anti-Infective Therapy
|August 5, 2020
PubMed

Insights

The COVID-19 pandemic requires urgent development of new treatments and vaccines. Translational research is crucial for creating targeted therapies and effective vaccines to control the global health crisis.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) emerged in December 2019 and was declared a pandemic by the WHO in March 2020.
  • Current COVID-19 management focuses on supportive care to prevent respiratory failure.
  • Antiviral therapies and vaccines for COVID-19 are under active evaluation and development.

Purpose of the Study:

  • To review the current knowledge on viral replication, pathogenicity, diagnostics, and therapeutics for COVID-19.
  • To contribute to the development of vaccines and targeted therapies for pandemic containment.
  • To inform scientists and clinicians on the latest advancements in COVID-19 research.

Main Methods:

  • A comprehensive literature search was conducted using PubMed.
  • The search covered the period from December 1, 2019, to June 23, 2020.
  • The review synthesizes information on viral characteristics, clinical management, and therapeutic strategies.

Main Results:

  • The review details the current understanding of SARS-CoV-2 replication and pathogenicity.
  • It outlines existing and emerging diagnostic and therapeutic strategies for COVID-19.
  • The current state of vaccine development is also highlighted.

Conclusions:

  • An exit strategy necessitates the development of novel treatments and a successful vaccine.
  • Translational research (bench-to-bedside and bedside-to-bench) is vital for developing targeted drugs and vaccines.
  • Continued research is essential to protect public health and prevent future outbreaks.
Abstract

Keywords:
COVID-19SARS-CoV-2diagnosissevere acute respiratory syndrome coronavirus-2treatment

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