Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental study of iron effect on the liver function.

M Hasegawa1, H Takenaka, A Shinotsuka

  • 1Department of Radiology, Showa University School of Medicine, Tokyo, Japan.

Annals of Nuclear Medicine
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Necrotizing Sweet syndrome in a patient with myelodysplastic syndrome.

Clinical and experimental dermatology·2017
Same author

Demonstration of the high collection efficiency of a broadband Mo/Si multilayer mirror with a graded multilayer coating on an ellipsoidal substrate.

The Review of scientific instruments·2015
Same author

Preparations ofN, N'-ethylene-bridged dipeptides(eXX) constructed from (S)-methionine, -tryptophan, -tyrosine and-N(ɛ)-benzyloxycarbonyllysine through acid-catalyzed cyclization.

Amino acids·2013
Same author

Prevalence and impact of rhinitis in asthma. SACRA, a cross-sectional nation-wide study in Japan.

Allergy·2011
Same author

Systemic lupus erythematosus following vaccination against 2009 influenza A (H1N1).

Lupus·2010
Same author

Large-area, high-resolution pattern replication by the use of a two-aspherical-mirror system.

Applied optics·2010

Iron overload can worsen liver damage, particularly in cases of carbon tetrachloride-induced liver injury. While iron boosts reticuloendothelial system function per liver weight, overall function remains unchanged due to decreased liver mass, leading to severe dysfunction when combined with liver damage.

Area of Science:

  • Hepatology
  • Toxicology
  • Biochemistry

Background:

  • Iron metabolism plays a critical role in liver function.
  • Liver injury can be induced by various toxins, including carbon tetrachloride.
  • The reticuloendothelial system (RES) and hepatocytes are key components of liver function.

Purpose of the Study:

  • To investigate the effects of iron administration on liver function in rats, both independently and in combination with carbon tetrachloride.
  • To evaluate the impact of iron on hepatocyte function and reticuloendothelial system (RES) function.

Main Methods:

  • Forty rats were divided into four groups: iron, carbon tetrachloride, iron + carbon tetrachloride, and control.
  • Liver function was assessed using hepatobiliary scintigraphy (hepatocyte function) and liver scintigraphy (RES function).

Related Experiment Videos

  • Liver CT number and histological studies were performed to evaluate structural changes and iron deposition.

    • Main Results:

    • Iron administration activated RES function per unit liver weight, but total RES function remained unchanged due to decreased liver weight.
    • Combined administration of iron and carbon tetrachloride resulted in liver cirrhosis and siderosis within the RES.
    • RES dysfunction was more severe in the iron + carbon tetrachloride group compared to the carbon tetrachloride-only group, while hepatocyte dysfunction was milder.

    Conclusions:

    • Iron administration alone does not significantly alter total RES function despite increased function per unit weight.
    • In the presence of carbon tetrachloride-induced liver injury, iron exacerbates RES dysfunction and leads to siderosis.
    • The timing of iron administration may influence its impact on liver fibrosis and blood flow, potentially affecting RES dysfunction.