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The Type IX Secretion System: Advances in Structure, Function and Organisation.

Dhana G Gorasia1, Paul D Veith1, Eric C Reynolds1

  • 1Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne VIC 3010, Australia.

Microorganisms
|August 6, 2020
PubMed
Summary
This summary is machine-generated.

The type IX secretion system (T9SS) in Bacteroidetes transports proteins and is crucial for virulence and motility. Recent research clarifies the T9SS machinery

Keywords:
Flavobacterium johnsoniaePorphyromonas gingivalisbacterial protein secretioncell-surface attachmenttype IX secretion system

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Area of Science:

  • Microbiology
  • Bacterial protein secretion

Background:

  • The type IX secretion system (T9SS) is unique to the Bacteroidetes phylum.
  • Porphyromonas gingivalis uses T9SS for virulence factor transport and cell surface attachment.
  • T9SS is essential for gliding motility in bacteria like Flavobacterium johnsoniae.

Purpose of the Study:

  • To review recent advancements in understanding the T9SS.
  • To elucidate the structure, function, and organization of the T9SS machinery.
  • To provide insights into the molecular mechanisms of this novel secretion system.

Main Methods:

  • Literature review of recent studies on T9SS.
  • Analysis of known T9SS protein components, including transcription regulators (PorX, PorY, SigP).
  • Focus on structural and functional data.

Main Results:

  • Nineteen T9SS components have been identified.
  • The overall organization and molecular mechanism of T9SS remain largely unknown.
  • Recent advances provide new insights into T9SS structure and function.

Conclusions:

  • The T9SS is a complex system with critical roles in bacterial physiology.
  • Further research is needed to fully understand T9SS organization and mechanism.
  • This review highlights key recent findings and future directions for T9SS research.