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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.
Daniela Bruni1, Helen K Angell2, Jérôme Galon3
1INSERM, Laboratory of Integrative Cancer Immunology; Équipe Labellisée Ligue Contre le Cancer; Sorbonne Université; Sorbonne Paris Cité; Université de Paris; Centre de Recherche des Cordeliers, Paris, France.
Nature Reviews. Cancer
|August 6, 2020
View abstract on PubMed
Summary
The Immunoscore, a measure of T cell infiltrate, shows promise in predicting cancer patient outcomes. This immune-based assay may offer superior prognostic value compared to traditional cancer staging systems.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- The American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system is standard for cancer classification.
- Significant variations in clinical outcomes exist among patients within the same TNM stage.
- Emerging research highlights the dynamic interaction between tumor cells and the immune system in cancer progression.
Purpose of the Study:
- To review immune parameters influencing cancer development and patient survival.
- To discuss the prognostic and predictive value of the Immunoscore assay.
- To explore the role of the immune system in cancer control and immunotherapy effectiveness.
Main Methods:
- Review of existing literature on cancer immunology and staging.
Main Results:
- The Immunoscore assay quantifies in situ T cell infiltrate.
- Immunoscore demonstrated superior prognostic value over AJCC/UICC TNM staging in colorectal cancer.
- Distinct immune cell types play a crucial role in modulating cancer progression.
Conclusions:
- The immune contexture, defined by pre-existing immune parameters, impacts patient survival.
- A pre-existing intratumoral adaptive immune response is essential for effective immunotherapies.
- Combining multiple immune parameters may enhance prognostic and predictive accuracy.


