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  1. Home
  2. The Immune Contexture And Immunoscore In Cancer Prognosis And Therapeutic Efficacy.
  1. Home
  2. The Immune Contexture And Immunoscore In Cancer Prognosis And Therapeutic Efficacy.

Related Experiment Video

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.

Daniela Bruni1, Helen K Angell2, Jérôme Galon3

  • 1INSERM, Laboratory of Integrative Cancer Immunology; Équipe Labellisée Ligue Contre le Cancer; Sorbonne Université; Sorbonne Paris Cité; Université de Paris; Centre de Recherche des Cordeliers, Paris, France.

Nature Reviews. Cancer
|August 6, 2020

View abstract on PubMed

Summary
This summary is machine-generated.

The Immunoscore, a measure of T cell infiltrate, shows promise in predicting cancer patient outcomes. This immune-based assay may offer superior prognostic value compared to traditional cancer staging systems.

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • The American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system is standard for cancer classification.
  • Significant variations in clinical outcomes exist among patients within the same TNM stage.
  • Emerging research highlights the dynamic interaction between tumor cells and the immune system in cancer progression.

Purpose of the Study:

  • To review immune parameters influencing cancer development and patient survival.
  • To discuss the prognostic and predictive value of the Immunoscore assay.
  • To explore the role of the immune system in cancer control and immunotherapy effectiveness.

Main Methods:

  • Review of existing literature on cancer immunology and staging.
  • Analysis of immune parameters, including tumor-infiltrating T cells.
  • Evaluation of the Immunoscore assay's performance in colorectal cancer.
  • Main Results:

    • The Immunoscore assay quantifies in situ T cell infiltrate.
    • Immunoscore demonstrated superior prognostic value over AJCC/UICC TNM staging in colorectal cancer.
    • Distinct immune cell types play a crucial role in modulating cancer progression.

    Conclusions:

    • The immune contexture, defined by pre-existing immune parameters, impacts patient survival.
    • A pre-existing intratumoral adaptive immune response is essential for effective immunotherapies.
    • Combining multiple immune parameters may enhance prognostic and predictive accuracy.