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Engineered Hydrogels for Brain Tumor Culture and Therapy
Jai Thakor1,2, Samad Ahadian1,2, Ali Niakan1
1Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA.
Bio-Design and Manufacturing
|August 6, 2020
Summary
Bioengineering using hydrogels creates 3D brain tumor models for studying tumor growth and developing new treatments. These advanced models aid in drug delivery and therapeutic strategies for brain tumors.
Area of Science:
- Biomedical Engineering
- Oncology
- Tissue Engineering
Background:
- Brain tumors exhibit a wide range of severity, from benign to aggressive.
- Understanding brain tumor pathophysiology is crucial for developing effective antitumoral treatments.
- Bioengineering offers tools to study tumors ex vivo and advance therapeutic strategies.
Purpose of the Study:
- To review the development of three-dimensional (3D) tissue models for brain tumors.
- To highlight the role of hydrogels in creating biomimetic environments for brain tumor cells.
- To discuss the application of microscale technologies and advanced cellular models in engineered tumor tissues.
Main Methods:
- Description of brain tumor physiology and cellular composition.
- Development of 3D tissue models using brain tumor cells within hydrogels.
- Integration of microscale technologies (electrospinning, bioprinting) and advanced cellular models.
Main Results:
- Hydrogels provide biomimetic support for 3D brain tumor growth and structure formation.
- Engineered tumor tissues mimic the extracellular matrix and cellular localization.
- Hydrogels show potential for drug delivery and combination therapies.
Conclusions:
- Hydrogels are valuable for creating in vitro models of brain tumors.
- Further development of hydrogel-based systems can advance therapeutic strategies.
- These engineered models hold promise for translational medicine in brain tumor treatment.
