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Updated: Dec 13, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Potential Treatment Options for COVID-19: A Comprehensive Review of Global Pharmacological Development Efforts

Karun Neupane1, Zahoor Ahmed2, Hira Pervez3

  • 1Internal Medicine, Manipal College of Medical Sciences, Pokhara, NPL.

Cureus
|August 6, 2020
PubMed

Insights

The COVID-19 pandemic necessitates effective treatments. This article reviews data from clinical trials on candidate drugs like remdesivir and hydroxychloroquine for treating SARS-CoV-2 infection.

Area of Science:

  • Infectious Diseases
  • Virology
  • Pharmacology

Background:

  • Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, rapidly became a global pandemic.
  • Over 8.7 million cases and 461,000 deaths were reported globally by June 20, 2020.
  • The escalating crisis created an urgent need for effective COVID-19 therapeutics.

Purpose of the Study:

  • To compile comprehensive data on candidate drugs for COVID-19 treatment.
  • To review clinical trial data for various therapeutic agents.
  • To provide an overview of ongoing drug development for SARS-CoV-2.

Main Methods:

  • Literature review and data compilation.
  • Tabulation of data from clinical trials on COVID-19 therapeutics.
  • Analysis of candidate drugs including remdesivir, favipiravir, hydroxychloroquine, and others.

Main Results:

  • A comprehensive list of candidate drugs for COVID-19 treatment is presented.
  • Data from multiple clinical trials investigating these drugs are tabulated.
  • The article covers a wide range of therapeutic agents being tested against SARS-CoV-2.

Conclusions:

  • Multiple drug development trials are underway for COVID-19 treatment.
  • Effective therapeutic options are crucial for managing the pandemic.
  • This compilation serves as a resource for understanding current COVID-19 therapeutic research.
Keywords:
coronaviruscovid-19hydroxychloroquineremdesivirsars-cov-2therapeuticstreatment

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