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The Control and Prevention of COVID-19 Transmission in Children: A Protocol for Systematic Review and Meta-analysis
Gidyenne Christine Bandeira Silva de Medeiros1, Ana Clara de França Nunes1, Kesley Pablo Morais de Azevedo1
1Department of Public Health, Postgraduate Program in Public Health, Federal University of Rio Grande do Norte, Natal/RN, Brazil.
Insights
This systematic review synthesizes evidence on COVID-19 in children and adolescents, focusing on transmission, clinical features, and prevention strategies. It aims to inform new control measures for the pediatric population.
Area of Science:
- Pediatric Infectious Diseases
- Epidemiology
- Public Health
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 has had a global impact, with limited data on pediatric populations.
- Understanding COVID-19 in children and adolescents is crucial for effective public health strategies.
Purpose of the Study:
- To systematically review evidence on the control and prevention of COVID-19 transmission in children and adolescents.
- To describe the epidemiological, clinical, and immunological characteristics of COVID-19 in pediatric populations.
- To identify the role of children and adolescents in SARS-CoV-2 transmission dynamics.
Main Methods:
- Systematic review protocol developed following PRISMA-P guidelines.
- Searches conducted across major databases (PubMed, Web of Science, Scopus, etc.) for relevant studies.
- Inclusion of clinical trials, observational studies, and case reports involving SARS-CoV-2 infected children and adolescents (≤19 years).
- Risk of bias assessment using established tools (Cochrane's RoB 2.0, ROBINS-I, CASP).
- Data synthesis through meta-analysis, subgroup, or descriptive analyses as appropriate.
Main Results:
- A comprehensive synthesis of evidence on the epidemiological profile of COVID-19 in children and adolescents.
- Detailed description of clinical and immunological characteristics associated with pediatric COVID-19 cases.
- Insights into the participation of pediatric populations in SARS-CoV-2 transmission dynamics.
Conclusions:
- This systematic review provides critical evidence for understanding COVID-19 in children and adolescents.
- Findings will support the development of targeted control and prevention strategies for the pediatric population.
- The study highlights the importance of continued research into pediatric infectious diseases.
Background:
The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population.
Methods:
This protocol will be developed in accordance with PRISMA-P. The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. Observational studies and case reports with Children and adolescents (≤19 years) infected with SARS-CoV-2 will be included whether they report information on the control of prevention and COVID-19 transmission. Two independent researchers will perform the selection of articles, removal of duplication, and screening by Rayyan QCRI application. Cochrane's RoB 2.0, ROBINS-I, and CASP tools will be used to assess the risk of bias. Meta-analysis, subgroup analyses, and/or descriptive analyses will be carried out based on the data conditions included.
Results:
A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided.
Conclusion:
This systematic review has an important relevance in the current context because it has a great potential to help the development of new control and prevention strategies in the pediatric population.
Record Of Systematic Review:
CRD42020179263.
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