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Assessment of cardio-ankle vascular index in patients with abdominal aortic aneurysm: An observational study

Ahmet Çağrı Aykan1,2, Mustafa Çetin3, Ezgi Kalaycıoğlu2

  • 1Department of Cardiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Vascular
|August 8, 2020
PubMed

Insights

Cardio-ankle vascular index (CAVI) is significantly higher in patients with abdominal aortic aneurysm (AAA), indicating increased arterial stiffness. This suggests CAVI may serve as a valuable marker for AAA risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Markers

Background:

  • Arterial stiffness is a known predictor of major adverse cardiovascular events.
  • Abdominal aortic aneurysm (AAA) is a serious vascular condition with significant morbidity and mortality.
  • Investigating markers of arterial stiffness in AAA patients is crucial for risk assessment.

Purpose of the Study:

  • To evaluate arterial stiffness using the cardio-ankle vascular index (CAVI) in patients diagnosed with abdominal aortic aneurysm (AAA).
  • To determine the relationship between CAVI and the severity of AAA.
  • To assess the potential of CAVI as a diagnostic and risk stratification tool for AAA.

Main Methods:

  • An observational, cross-sectional study was conducted.
  • Fifty-nine patients with AAA and 32 healthy controls were enrolled.
  • Cardio-ankle vascular index (CAVI) was measured using the VaSera-1000 instrument, supplemented by ultrasonography.

Main Results:

  • Patients with AAA exhibited significantly higher CAVI values compared to healthy controls (9.74 ± 1.50 vs. 7.60 ± 1.07, p < 0.001).
  • CAVI demonstrated a positive correlation with abdominal aortic diameter (r = 0.461, p < 0.001) and a negative correlation with left ventricle ejection fraction (r = -0.254, p = 0.015).
  • Receiver operating characteristic (ROC) analysis indicated that a CAVI cutoff of >8.3 had 89.8% sensitivity and 78.1% specificity for predicting AAA (AUC = 0.897, p < 0.001).

Conclusions:

  • Elevated arterial stiffness, as indicated by CAVI, is present in patients with abdominal aortic aneurysm (AAA).
  • Increased arterial stiffness may represent a shared pathophysiological mechanism or a mechanical link between AAA and other cardiovascular diseases.
  • CAVI shows promise as a valuable biomarker for risk stratification in individuals susceptible to developing AAA.
Abstract

Keywords:
CAVIabdominal aortic aneurysmarterial stiffness

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