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Updated: Dec 12, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Intermittent fasting ameliorates PM2.5 exposure-induced abnormalities in glycaemic control
Wei Wei1, Ling Tang1, Minjie Chen2
1Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Bile Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Intermittent fasting can counteract negative effects of fine particulate matter (PM2.5) exposure on blood sugar control. This dietary approach may help prevent type 2 diabetes linked to air pollution.
Area of Science:
- Environmental Health
- Metabolic Diseases
- Nutritional Science
Background:
- Ambient fine particulate matter (PM2.5) exposure is linked to metabolic dysfunction and type 2 diabetes.
- Intermittent fasting is a recognized intervention for managing type 2 diabetes.
Purpose of the Study:
- To investigate if intermittent fasting mitigates glucose metabolism abnormalities caused by PM2.5 exposure.
- To assess the impact of intermittent fasting on PM2.5-induced insulin resistance and glucose intolerance.
Main Methods:
- Mice were exposed to filtered air or concentrated ambient PM2.5 for 16 weeks.
- Mice were concurrently subjected to ad libitum feeding or intermittent fasting.
- Glucose homeostasis, insulin signaling (Akt phosphorylation), and body weight were assessed.
Main Results:
- PM2.5 exposure induced insulin resistance, glucose intolerance, and increased glucose-induced insulin secretion.
- Intermittent fasting ameliorated PM2.5-induced insulin resistance and glucose intolerance.
- PM2.5 exposure reduced insulin signaling in the liver and adipose tissue; intermittent fasting improved liver insulin signaling.
Conclusions:
- Intermittent fasting effectively counteracts PM2.5-induced insulin resistance and glucose intolerance.
- Intermittent fasting shows potential as a strategy to prevent type 2 diabetes in individuals exposed to PM2.5 air pollution.
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