Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The double crush syndrome.

A L Osterman1

  • 1Hospital of the University of Pennsylvania, Philadelphia.

The Orthopedic Clinics of North America
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

The double crush syndrome, where a proximal nerve lesion increases distal nerve vulnerability, impacts surgical outcomes. Identifying this condition is crucial for managing peripheral nerve entrapments effectively.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mid-term outcomes of routine proximal row carpectomy compared with proximal row carpectomy with dorsal capsular interposition arthroplasty for the treatment of late-stage arthropathy of the wrist.

The bone & joint journal·2018
Same author

Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy.

Oncogene·2017
Same author

Metabolic rewiring in melanoma.

Oncogene·2016
Same author

Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure.

Cell death & disease·2016
Same author

Experimental determination and system level analysis of essential genes in Escherichia coli MG1655.

Journal of bacteriology·2003
Same author

Partial interosseous ligament tears of the wrist: difficulty in utilizing either primary or secondary MRI signs.

Journal of computer assisted tomography·2001
Same journal

New Technologies.

The Orthopedic clinics of North America·2026
Same journal

Recent Innovations and Applications of Custom 3D Printed Cages for Critical Bone Defects in Foot and Ankle Surgery.

The Orthopedic clinics of North America·2026
Same journal

Application of New Technologies: Patient-specific Instrumentation and Artificial Intelligence in the Field of Foot and Ankle.

The Orthopedic clinics of North America·2026
Same journal

Robotic-Assisted Latissimus Dorsi Transfers Around the Shoulder.

The Orthopedic clinics of North America·2026
Same journal

Blood Flow Restriction Therapy for the Upper Extremity: An Emerging Adjunct for Patient Recovery and Rehabilitation.

The Orthopedic clinics of North America·2026
Same journal

The Emerging Roles for 3 Dimensional Printing in Orthopedics: Applications, Evidence, and Future Directions.

The Orthopedic clinics of North America·2026
See all related articles

Area of Science:

  • Neurology
  • Orthopedics
  • Neurosurgery

Background:

  • Multilevel lesions affecting peripheral nerves are recognized clinical entities.
  • The double crush syndrome describes how a proximal nerve lesion can sensitize a distal nerve segment to secondary compression.
  • Axonal transport disturbances and neurofilament alterations are hypothesized pathophysiological mechanisms.

Purpose of the Study:

  • To investigate the clinical implications of the double crush syndrome.
  • To evaluate the impact of proximal nerve compression on distal nerve entrapment symptoms and surgical outcomes.
  • To emphasize the importance of preoperative identification of double crush lesions.

Main Methods:

  • Clinical observation and patient studies were conducted.

Related Experiment Videos

  • Comparison of carpal tunnel syndrome severity and surgical outcomes between patients with and without evidence of proximal nerve compression.
  • Assessment of median nerve involvement in relation to proximal root compression.

    • Main Results:

    • Proximal root compression reduced the threshold for median nerve symptoms at the carpal tunnel.
    • Surgical release of carpal tunnel entrapment yielded poorer outcomes in patients with coexisting proximal lesions compared to isolated carpal tunnel involvement.
    • Preoperative identification of double crush lesions can predict suboptimal surgical results.

    Conclusions:

    • The double crush syndrome significantly influences the presentation and treatment outcomes of peripheral nerve entrapments.
    • Preoperative screening for proximal nerve lesions is essential in patients presenting with distal nerve entrapment symptoms.
    • Optimal management of double crush syndrome often necessitates addressing both proximal and distal nerve compressions.