Antibiotic resistance of the nasopharynx microbiota in patients with inflammatory processes

The aim: To study the species composition of microorganisms isolated from patients with inflammatory processes of different localization and to monitor the sensitivity of isolated microorganisms to the most commonly used antibiotics.

Materials and methods: During 2017-2019, we examined 517 patients with acute inflammatory processes of the nasopharynx. To establish the etiological structure of pathogens of inflammatory processes, a microbiological study of nasopharyngeal washes was carried out using classical methods of isolation and identification of microorganisms. The sampling of the test material from patients was performed during the first visit to a doctor, before the appointment and implementation of etiopathogenetic therapy. To study the sensitivity of isolated microorganisms to antibacterial drugs, we used the method of paper disks (manufactured by "Pharmaktiv" Ltd. (Kyiv, Ukraine) and Himedia (India).

Results and conclusions:The microflora of the mucous membranes of the nose and throat in patients with acute inflammatory processes of the nasopharynx is represented mainly by monoisolates of staphylococci and streptococci. The sensitivity of isolated microorganisms to antibiotics varied between different types of microorganisms and between different antibiotics.Cefazolin showed efficacy against all types of microorganisms. K. pneumonia strains showed the highest antibiotic resistance. Among the gram-positive cocci, 18 strains (4.2%) resistant to all antibiotics were isolated, which can be regarded as the circulation of hospital strains outside the medical institutions.