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Plasma Biomarker for Post-concussive Syndrome: A Pilot Study Using an Alternating Current Electro-Kinetic Platform.

Jean M Lewis1, Sanjay Dhawan2, Augustine C Obirieze1

  • 1Department of Nanoengineering, University of California, San Diego, San Diego, CA, United States.

Frontiers in Neurology
|August 8, 2020
PubMed
Summary
This summary is machine-generated.

This study shows an alternating current electrokinetic (ACE) microchip can detect biomarkers for traumatic brain injury (TBI). The ACE microchip shows promise for diagnosing TBI and understanding post-concussive symptoms.

Keywords:
alternating current electrokineticsbiomarkersconcussionextracellular vesiclestraumatic brain injury

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Area of Science:

  • Biomarker discovery
  • Neuroscience
  • Medical diagnostics

Background:

  • Traumatic brain injury (TBI) diagnosis requires improved technology for biomarker discovery.
  • An observational pilot study explored the use of an alternating current electrokinetic (ACE) microchip device for TBI biomarker analysis.

Purpose of the Study:

  • To evaluate the utility of an ACE microchip for detecting plasma biomarkers in patients with and without minor TBI.
  • To correlate biomarker levels with post-concussive symptoms.

Main Methods:

  • Blood samples were collected from individuals with and without minor TBI.
  • Plasma levels of GFAP, Tau, UCH-L1, and cfDNA were measured using an ACE microchip with immunofluorescent analysis.
  • Post-concussive symptoms were assessed using the Rivermead Post Concussion Symptoms Questionnaire (RPCSQ).

Main Results:

  • GFAP, UCH-L1, and Tau levels were highest in TBI subjects with abnormal head CT scans.
  • Plasma GFAP and Tau levels differentiated between minor TBI and non-TBI patients (64-72% sensitivity).
  • Biomarker levels strongly correlated with cumulative RPCSQ scores, including sensitivity to noise/light, headache, sleep disturbance, and cognitive symptoms.

Conclusions:

  • The ACE microchip device shows proof-of-principle utility for plasma biomarker analysis in minor TBI patients.
  • This technology may aid in TBI diagnosis and symptom assessment.
  • Further research is warranted to validate these findings in larger cohorts.