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Updated: Dec 12, 2025
Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
Targeted DNA-driven catalytic assembly light-up ratiometric fluorescence of biemissive silver nanoclusters for
Jiayang He1, Yuxuan Zhang, Zehui Chen
1Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. xwju@swu.edu.cn yuanruo@swu.edu.cn.
Abstract:
The isothermal assembly of a target-recognizable hairpin and a catalytic hairpin was driven by specific HIV-related DNA (hDNA) as a test model, outputting amplified duplexes to open a functional hairpin beacon (HB) tethering the templates of biemissive (green and red) silver nanoclusters (G-AgNCs and R-AgNCs). As such, their ratiometric fluorescence was remarkably lit up, achieving rapid, specific and sensitive biosensing with potential for disease diagnosis and biomolecule detection.
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