Related Experiment Video
Updated: Dec 12, 2025
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Prominent coagulation disorder is closely related to inflammatory response and could be as a prognostic indicator for
Yang Liu1, Weibo Gao2, Wei Guo3
1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, No. 11 Xi-Zhi-Men South Street, Beijing, 100044, China.
Insights
COVID-19 patients in ICUs often exhibit blood coagulation disorders, linked to inflammation. Abnormal blood clotting markers indicate a poorer prognosis for critically ill COVID-19 patients.
Area of Science:
- Critical Care Medicine
- Hematology
- Infectious Diseases
Background:
- The Coronavirus Disease 2019 (COVID-19) outbreak poses a significant global health challenge.
- Understanding blood coagulation abnormalities in COVID-19 patients is crucial for patient management.
Purpose of the Study:
- To investigate the characteristics of blood coagulation abnormalities in intensive care unit (ICU) patients with COVID-19.
- To explore the correlation between coagulation parameters and inflammatory markers, clinical severity scores, and patient outcomes.
Main Methods:
- Retrospective analysis of 147 consecutive COVID-19 patients admitted to ICUs in Wuhan.
- Evaluation of baseline coagulation parameters, inflammatory markers, and clinical data.
- Correlation analysis with severity scores (APACHE II, SOFA, qSOFA) and in-hospital mortality.
Main Results:
- Prolonged prothrombin time (PT), fibrinogen degradation products (FDP), and D-dimer (DD) correlated positively with inflammatory markers and negatively with lymphocyte levels.
- Antithrombin III (ATIII) levels showed significant negative correlations with neutrophils, ferritin, LDH, total bilirubin, and specific cytokines.
- Coagulation abnormalities were more pronounced in patients with Acute Respiratory Distress Syndrome (ARDS) and Acute Kidney Injury (AKI).
- PT, DD, and FDP levels positively correlated with severity scores, while ATIII levels correlated negatively.
- Elevated PT, FDP, and DD levels were associated with increased in-hospital mortality.
Conclusions:
- Blood coagulation disorders are prominent in ICU patients with COVID-19 and are associated with systemic inflammation.
- Abnormalities in coagulation parameters serve as potential adverse prognostic indicators for critically ill COVID-19 patients.
Abstract:
The new outbreak of Coronavirus Disease 2019 (COVID-19) has emerged as a serious global public health concern. A more in-depth study of blood coagulation abnormality is needed. We retrospectively analyzed 147 consecutive patients with COVID-19 who were admitted to three ICUs in Wuhan from February 9th, 2020 to March 20th, 2020. The baseline coagulation and other characteristics were studied. Our results showed that the prolonged PT, FDP, DD were positively correlated with the levels of neutrophils, ferritin, LDH, total bilirubin, multi-inflammation cytokines, and negatively correlated with the lymphocytes level (p < 0.01). The level of ATIII was significantly negatively correlated with the levels of neutrophils, ferritin, LDH, total bilirubin, IL2R, IL6 and IL8 (p < 0.05). The patients in the ARDS group had a more prominent abnormality in PT, FDP, DD and ATIII, while the patients in the AKI group had more prolonged PT, more severe FDP and DD level, more inferior ATIII and Fib level than those in the non-AKI group (p < 0.01). The value of PT, DD and FDP were positively correlated with the classical APACHE II, SOFA and qSOFA scores, while the ATIII was negatively correlated with them (p < 0.001). The high levels of PT, FDP and DD were correlated with in-hospital mortality (p < 0.001). In conclusion, blood coagulation disorder was prominent in ICU patients with COVID-19 and was correlated with multi-inflammation factors. The abnormality of blood coagulation parameters could be an adverse prognostic indicator for ICU patients with COVID-19.
More Related Videos
04:56Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
Published on: August 4, 2023
09:38A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Related Concept Videos
01:09Coagulation
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
01:06Coagulation
01:24Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
01:20Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
01:29Venous Thrombosis III: Interprofessional Care