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Updated: Dec 12, 2025

Sexual Development and Ascospore Discharge in Fusarium graminearum
Published on: March 29, 2012
Fusapyrone A, a γ-pyrone derived from a desert Fusarium sp
Xin Zhen1, Meng-Jia Mao1,2, Ren-Zhong Wang1
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
In this work, we isolated and characterized fusapyrone A (1), a new γ-pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of 13C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC50 of 50.6 μM.[Formula: see text].
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